Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion

Gene regulatory interactions underlying the early stages of non-genotoxic carcinogenesis are poorly understood. Here, we have identified key candidate regulators of phenobarbital (PB)-mediated mouse liver tumorigenesis, a well-characterized model of non-genotoxic carcinogenesis, by applying a new co...

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Main Authors: Luisier, Raphaëlle, Unterberger, Elif B., Goodman, Jay I., Schwarz, Michael, Moggs, Jonathan, Terranova, Rémi, van Nimwegen, Erik
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Computational Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985636/
https://ncbi.nlm.nih.gov/pubmed/24464994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1415
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