Structure determination of noncanonical RNA motifs guided by (1)H NMR chemical shifts

Structured non-coding RNAs underline fundamental cellular processes, but determining their 3D structures remains challenging. We demonstrate herein that integrating NMR (1)H chemical shift data with Rosetta de novo modeling can consistently return high-resolution RNA structures. On a benchmark set o...

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Hlavní autoři: Sripakdeevong, Parin, Cevec, Mirko, Chang, Andrew T., Erat, Michèle C., Ziegeler, Melanie, Zhao, Qin, Fox, George E., Gao, Xiaolian, Kennedy, Scott D., Kierzek, Ryszard, Nikonowicz, Edward P., Schwalbe, Harald, Sigel, Roland K. O., Turner, Douglas H., Das, Rhiju
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985481/
https://ncbi.nlm.nih.gov/pubmed/24584194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2876
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