Structure determination of noncanonical RNA motifs guided by (1)H NMR chemical shifts

Structured non-coding RNAs underline fundamental cellular processes, but determining their 3D structures remains challenging. We demonstrate herein that integrating NMR (1)H chemical shift data with Rosetta de novo modeling can consistently return high-resolution RNA structures. On a benchmark set o...

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Detalhes bibliográficos
Main Authors: Sripakdeevong, Parin, Cevec, Mirko, Chang, Andrew T., Erat, Michèle C., Ziegeler, Melanie, Zhao, Qin, Fox, George E., Gao, Xiaolian, Kennedy, Scott D., Kierzek, Ryszard, Nikonowicz, Edward P., Schwalbe, Harald, Sigel, Roland K. O., Turner, Douglas H., Das, Rhiju
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985481/
https://ncbi.nlm.nih.gov/pubmed/24584194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2876
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