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Calcium Inhibition of Ribonuclease H1 Two-Metal Ion Catalysis

[Image: see text] Most phosphate-processing enzymes require Mg(2+) as a cofactor to catalyze nucleotide cleavage and transfer reactions. Ca(2+) ions inhibit many of these enzymatic activities, despite Ca(2+) and Mg(2+) having comparable binding affinities and overall biological abundances. Here we s...

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Detalhes bibliográficos
Main Authors: Rosta, Edina, Yang, Wei, Hummer, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985467/
https://ncbi.nlm.nih.gov/pubmed/24499076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja411408x
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