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Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release
In two-metal catalysis, metal ion A has been proposed to activate the nucleophile and metal ion B to stabilize the transition state. We recently reported crystal structures of RNase H–RNA/DNA substrate complexes obtained at 1.5–2.2 Å. We have now determined and report here structures of reaction int...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456928/ https://ncbi.nlm.nih.gov/pubmed/16601679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601076 |
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