Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases

The 2.15-Å resolution cocrystal structure of EcoRV endonuclease mutant T93A complexed with DNA and Ca(2+) ions reveals two divalent metals bound in one of the active sites. One of these metals is ligated through an inner-sphere water molecule to the phosphate group located 3′ to the scissile phospha...

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Bibliografiska uppgifter

I publikationen:	Proc Natl Acad Sci U S A
Huvudupphov:	Horton, Nancy C., Newberry, Kate Juliet, Perona, John J.
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	National Academy of Sciences 1998
Ämnen:	Biological Sciences
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811827/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13489
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