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Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases

The 2.15-Å resolution cocrystal structure of EcoRV endonuclease mutant T93A complexed with DNA and Ca(2+) ions reveals two divalent metals bound in one of the active sites. One of these metals is ligated through an inner-sphere water molecule to the phosphate group located 3′ to the scissile phospha...

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Detaylı Bibliyografya
Asıl Yazarlar: Horton, Nancy C., Newberry, Kate Juliet, Perona, John J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 1998
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC24846/
https://ncbi.nlm.nih.gov/pubmed/9811827
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