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Prickle1 stunts limb growth through alteration of cell polarity and gene expression

BACKGROUND: Wnt/PCP signaling plays a critical role in multiple developmental processes, including limb development. Wnt5a, a ligand of the PCP pathway, signals through the Ror2/Vangl2 or the Vangl2/Ryk complex to regulate limb development along the proximal-distal axis in mice. Based on the interac...

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Detalhes bibliográficos
Main Authors: Yang, Tian, Bassuk, Alexander G., Fritzsch, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985166/
https://ncbi.nlm.nih.gov/pubmed/23913870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.24025
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