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prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies
Recent analyses in flies, mice, zebrafish, and humans showed that mutations in prickle orthologs result in epileptic phenotypes, although the mechanism responsible for generating the seizures was unknown. Here, we show that Prickle organizes microtubule polarity and affects their growth dynamics in...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4121842/ https://ncbi.nlm.nih.gov/pubmed/25024231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403357111 |
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