Open and Closed Conformations of the Isolated Transmembrane Domain of Death Receptor 5 Support a New Model of Activation

It has long been presumed that activation of the apoptosis-initiating Death Receptor 5, as well as other structurally homologous members of the TNF-receptor superfamily, relies on ligand-stabilized trimerization of noninteracting receptor monomers. We and others have proposed an alternate model in w...

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Detalles Bibliográficos
Autores principales: Lewis, Andrew K., James, Zachary M., McCaffrey, Jesse E., Braun, Anthony R., Karim, Christine B., Thomas, David D., Sachs, Jonathan N.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2014
Materias:
Biophysical Letter
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984993/
https://ncbi.nlm.nih.gov/pubmed/24655519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.01.044
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