Stress gates neural activation of BDNF in the mesolimbic reward pathway

BDNF, acting in the mesolimbic dopamine reward pathway, promotes susceptibility to stress; however, the mechanisms controlling its release remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF levels in nucleus accumbens (NAc) of socially stressed mice, but not...

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Autori principali: Walsh, Jessica J., Friedman, Allyson K., Sun, Haosheng, Heller, Elizabeth A., Ku, Stacy M., Juarez, Barbara, Burnham, Veronica L., Mazei-Robison, Michelle S., Ferguson, Deveroux, Golden, Sam A., Koo, Ja Wook, Chaudhury, Dipesh, Christoffel, Daniel J., Pomeranz, Lisa, Friedman, Jeffrey M., Russo, Scott J., Nestler, Eric J., Han, Ming-Hu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984932/
https://ncbi.nlm.nih.gov/pubmed/24270188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3591
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