Stress gates neural activation of BDNF in the mesolimbic reward pathway

BDNF, acting in the mesolimbic dopamine reward pathway, promotes susceptibility to stress; however, the mechanisms controlling its release remain unknown. We report that phasic optogenetic activation of this pathway increases BDNF levels in nucleus accumbens (NAc) of socially stressed mice, but not...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Walsh, Jessica J., Friedman, Allyson K., Sun, Haosheng, Heller, Elizabeth A., Ku, Stacy M., Juarez, Barbara, Burnham, Veronica L., Mazei-Robison, Michelle S., Ferguson, Deveroux, Golden, Sam A., Koo, Ja Wook, Chaudhury, Dipesh, Christoffel, Daniel J., Pomeranz, Lisa, Friedman, Jeffrey M., Russo, Scott J., Nestler, Eric J., Han, Ming-Hu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984932/
https://ncbi.nlm.nih.gov/pubmed/24270188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3591
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