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The effect of the neonatal Fc receptor on human IgG biodistribution in mice
The neonatal Fc receptor (FcRn) plays a pivotal role in IgG homeostasis, i.e., it salvages IgG antibodies from lysosomal degradation following fluid-phase pinocytosis, thus preventing rapid systemic elimination of IgG. Recombinant therapeutic antibodies are typically composed of human or humanized s...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984338/ https://ncbi.nlm.nih.gov/pubmed/24492305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27765 |
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