The effect of the neonatal Fc receptor on human IgG biodistribution in mice

The neonatal Fc receptor (FcRn) plays a pivotal role in IgG homeostasis, i.e., it salvages IgG antibodies from lysosomal degradation following fluid-phase pinocytosis, thus preventing rapid systemic elimination of IgG. Recombinant therapeutic antibodies are typically composed of human or humanized s...

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Bibliographic Details
Main Authors: Chen, Nancy, Wang, Weirong, Fauty, Scott, Fang, Yulin, Hamuro, Lora, Hussain, Azher, Prueksaritanont, Thomayant
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984338/
https://ncbi.nlm.nih.gov/pubmed/24492305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27765
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