Characterization and screening of IgG binding to the neonatal Fc receptor

The neonatal Fc receptor (FcRn) protects immunoglobulin G (IgG) from degradation and increases the serum half-life of IgG, thereby contributing to a higher concentration of IgG in the serum. Because altered FcRn binding may result in a reduced or prolonged half-life of IgG molecules, it is advisable...

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Autores principales: Neuber, Tobias, Frese, Katrin, Jaehrling, Jan, Jäger, Sebastian, Daubert, Daniela, Felderer, Karin, Linnemann, Mechthild, Höhne, Anne, Kaden, Stefan, Kölln, Johanna, Tiller, Thomas, Brocks, Bodo, Ostendorp, Ralf, Pabst, Stefan
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171027/
https://ncbi.nlm.nih.gov/pubmed/24802048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28744
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