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In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators

Hair follicle stem cells (HFSCs) regenerate hair in response to Wnt signalling. Here, we unfold genome-wide transcriptional and chromatin landscapes of β-catenin–TCF3/4–TLE circuitry, and genetically dissect their biological roles within the native HFSC niche. We show that during HFSC quiescence, TC...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lien, Wen-Hui, Polak, Lisa, Lin, Mingyan, Lay, Kenneth, Zheng, Deyou, Fuchs, Elaine
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984009/
https://ncbi.nlm.nih.gov/pubmed/24463605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2903
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