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Silicate Esters of Paclitaxel and Docetaxel: Synthesis, Hydrophobicity, Hydrolytic Stability, Cytotoxicity, and Prodrug Potential
[Image: see text] We report here the synthesis and selected properties of various silicate ester derivatives (tetraalkoxysilanes) of the taxanes paclitaxel (PTX) and docetaxel (DTX) [i.e., PTX-OSi(OR)(3) and DTX-OSi(OR)(3)]. Both the hydrophobicity and hydrolytic lability of these silicates can be (...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical
Society
2014
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983351/ https://ncbi.nlm.nih.gov/pubmed/24564494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401708f |
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