Nanoparticles Containing High Loads of Paclitaxel Silicate Prodrugs: Formulation, Drug Release, and Anti-cancer Efficacy

We have investigated particle size, interior structure, drug release kinetics, and anticancer efficacy of PEG-b-PLGA-based nanoparticles loaded with a series of paclitaxel (PTX) silicate prodrugs [PTX-Si(OR)(3)]. Silicate derivatization enabled us to adjust the hydrophobicity and hydrolytic lability...

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Bibliografiske detaljer
Udgivet i:Mol Pharm
Main Authors: Han, Jing, Michel, Andrew R., Lee, Han Seung, Kalscheuer, Stephen, Wohl, Adam, Hoye, Thomas R., McCormick, Alon V., Panyam, Jayanth, Macosko, Christopher W.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4729777/
https://ncbi.nlm.nih.gov/pubmed/26505116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00530
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