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Silicate Esters of Paclitaxel and Docetaxel: Synthesis, Hydrophobicity, Hydrolytic Stability, Cytotoxicity, and Prodrug Potential

[Image: see text] We report here the synthesis and selected properties of various silicate ester derivatives (tetraalkoxysilanes) of the taxanes paclitaxel (PTX) and docetaxel (DTX) [i.e., PTX-OSi(OR)(3) and DTX-OSi(OR)(3)]. Both the hydrophobicity and hydrolytic lability of these silicates can be (...

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Detalhes bibliográficos
Main Authors: Wohl, Adam R., Michel, Andrew R., Kalscheuer, Stephen, Macosko, Christopher W., Panyam, Jayanth, Hoye, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983351/
https://ncbi.nlm.nih.gov/pubmed/24564494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401708f
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