A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

[Image: see text] The bioavailability of aromatic azaheterocyclic drugs can be affected by the activity of aldehyde oxidase (AO). Susceptibility to AO metabolism is difficult to predict computationally and can be complicated in vivo by differences between species. Here we report the use of bis(((dif...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: O’Hara, Fionn, Burns, Aaron C., Collins, Michael R., Dalvie, Deepak, Ornelas, Martha A., Vaz, Alfin D. N., Fujiwara, Yuta, Baran, Phil S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2014
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983350/
https://ncbi.nlm.nih.gov/pubmed/24472070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4017976
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