Synthesis and Biological Evaluation of New Carbohydrate-Substituted Indenoisoquinoline Topoisomerase I Inhibitors and Improved Syntheses of the Experimental Anticancer Agents Indotecan (LMP400) and Indimitecan (LMP776)

[Image: see text] Carbohydrate moieties were strategically transported from the indolocarbazole topoisomerase I (Top1) inhibitor class to the indenoisoquinoline system in search of structurally novel and potent Top1 inhibitors. The syntheses and biological evaluation of 20 new indenoisoquinolines gl...

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Detaylı Bibliyografya
Asıl Yazarlar: Beck, Daniel E., Agama, Keli, Marchand, Christophe, Chergui, Adel, Pommier, Yves, Cushman, Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983348/
https://ncbi.nlm.nih.gov/pubmed/24517248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401814y
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