Diamidine Compounds for Selective Inhibition of Protein Arginine Methyltransferase 1

[Image: see text] Protein arginine methylation is a posttranslational modification critical for a variety of biological processes. Misregulation of protein arginine methyltransferases (PRMTs) has been linked to many pathological conditions. Most current PRMT inhibitors display limited specificity an...

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Bibliografiska uppgifter
Huvudupphovsmän: Yan, Leilei, Yan, Chunli, Qian, Kun, Su, Hairui, Kofsky-Wofford, Stephanie A., Lee, Wei-Chao, Zhao, Xinyang, Ho, Meng-Chiao, Ivanov, Ivaylo, Zheng, Yujun George
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983339/
https://ncbi.nlm.nih.gov/pubmed/24564570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401884z
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