Least activation path for protein folding: investigation of staphylococcal nuclease folding by stopped-flow circular dichroism.
Is the pathway of protein folding determined by the relative stability of folding intermediates, or by the relative height of the activation barriers leading to these intermediates? This is a fundamental question for resolving the Levinthal paradox, which stated that protein folding by a random sear...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39833/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8637910/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.6.2539 |
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