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Preclinical Studies on Neurobehavioral and Neuromuscular Effects of Cocaine Hydrolase Gene Therapy in Mice

Cocaine hydrolase gene transfer of mutated human butyrylcholinesterase (BChE) is evolving as a promising therapy for cocaine addiction. BChE levels after gene transfer can be 1,500-fold above those in untreated mice, making this enzyme the second most abundant plasma protein. Because mutated BChE is...

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Main Authors: Murthy, Vishakantha, Gao, Yang, Geng, Liyi, LeBrasseur, Nathan, White, Thomas, Brimijoin, Stephen
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983183/
https://ncbi.nlm.nih.gov/pubmed/24085526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-013-0130-5
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