EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and is uniformly lethal. T-cell-based immunotherapy offers a promising platform for treatment given its potential to specifically target tumor tissue while sparing the normal brain. However, the diffuse and infiltrative na...

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Detalhes bibliográficos
Main Authors: Miao, Hongsheng, Choi, Bryan D., Suryadevara, Carter M., Sanchez-Perez, Luis, Yang, Shicheng, De Leon, Gabriel, Sayour, Elias J., McLendon, Roger, Herndon, James E., Healy, Patrick, Archer, Gary E., Bigner, Darell D., Johnson, Laura A., Sampson, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983153/
https://ncbi.nlm.nih.gov/pubmed/24722266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094281
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