EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and is uniformly lethal. T-cell-based immunotherapy offers a promising platform for treatment given its potential to specifically target tumor tissue while sparing the normal brain. However, the diffuse and infiltrative na...

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Autors principals: Miao, Hongsheng, Choi, Bryan D., Suryadevara, Carter M., Sanchez-Perez, Luis, Yang, Shicheng, De Leon, Gabriel, Sayour, Elias J., McLendon, Roger, Herndon, James E., Healy, Patrick, Archer, Gary E., Bigner, Darell D., Johnson, Laura A., Sampson, John H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983153/
https://ncbi.nlm.nih.gov/pubmed/24722266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094281
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