The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

Membrane fusion is generally controlled by Rabs, soluble N-ethylmaleimide–sensitive factor attachment protein receptors (SNAREs), and tethering complexes. Syntaxin 17 (STX17) was recently identified as the autophagosomal SNARE required for autophagosome–lysosome fusion in mammals and Drosophila. In...

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Main Authors: Jiang, Peidu, Nishimura, Taki, Sakamaki, Yuriko, Itakura, Eisuke, Hatta, Tomohisa, Natsume, Tohru, Mizushima, Noboru
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982997/
https://ncbi.nlm.nih.gov/pubmed/24554770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-08-0447
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