Potentiation of Colon Cancer Susceptibility in Mice by Colonic Epithelial PPAR-δ/β Overexpression

BACKGROUND: The nuclear receptor peroxisome proliferator-activated receptor-δ/β (PPAR-d) is upregulated in human colorectal cancers, but its role in colonic tumorigenesis remains controversial. METHODS: We generated a novel mouse model of intestinally targeted PPAR-d overexpression to simulate PPAR-...

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Hlavní autoři: Zuo, Xiangsheng, Xu, Min, Yu, Jiang, Wu, Yuanqing, Moussalli, Micheline J., Manyam, Ganiraju C., Lee, Sun Il, Liang, Shoudan, Gagea, Mihai, Morris, Jeffrey S., Broaddus, Russell R., Shureiqi, Imad
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982893/
https://ncbi.nlm.nih.gov/pubmed/24681603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju052
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