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Targeted Genetic Disruption of Peroxisome Proliferator–Activated Receptor-δ and Colonic Tumorigenesis
Peroxisome proliferator–activated receptor-delta (PPAR-δ) is overexpressed in human colon cancer, but its contribution to colonic tumorigenesis is controversial. We generated a mouse model in which PPAR-δ was genetically disrupted in colonic epithelial cells by targeted deletion of exon 4. Eliminati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684551/ https://ncbi.nlm.nih.gov/pubmed/19436036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djp078 |
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