Targeted Genetic Disruption of Peroxisome Proliferator–Activated Receptor-δ and Colonic Tumorigenesis

Peroxisome proliferator–activated receptor-delta (PPAR-δ) is overexpressed in human colon cancer, but its contribution to colonic tumorigenesis is controversial. We generated a mouse model in which PPAR-δ was genetically disrupted in colonic epithelial cells by targeted deletion of exon 4. Eliminati...

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Bibliografiske detaljer
Main Authors: Zuo, Xiangsheng, Peng, Zhanglong, Moussalli, Micheline J., Morris, Jeffrey S., Broaddus, Russell R., Fischer, Susan M., Shureiqi, Imad
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Brief Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684551/
https://ncbi.nlm.nih.gov/pubmed/19436036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djp078
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