Large electrostatic differences in the binding thermodynamics of a cationic peptide to oligomeric and polymeric DNA.

Results presented here demonstrate that the thermodynamics of oligocation binding to polymeric and oligomeric DNA are not equivalent because of long-range electrostatic effects. At physiological cation concentrations (0.1-0.3 M) the binding of an oligolysine octacation KWK6-NH2 (+8 charge) to single...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Zhang, W, Bond, J P, Anderson, C F, Lohman, T M, Record, M T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39828/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8637905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.6.2511
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