Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous epithelial stem cell proliferation

Kindlin-1 is an integrin tail binding protein that controls integrin activation. Mutations in the FERMT-1 gene lead to Kindler Syndrome in man, which is characterized by skin blistering, premature skin ageing and skin cancer of unknown etiology. Here we show that loss of Kindlin-1 in mouse keratinoc...

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Detalhes bibliográficos
Main Authors: Rognoni, Emanuel, Widmaier, Moritz, Jakobson, Madis, Ruppert, Raphael, Ussar, Siegfried, Katsougkri, Despoina, Böttcher, Ralph T., Lai-Cheong, Joey E., Rifkin, Daniel B., McGrath, John A., Fässler, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982140/
https://ncbi.nlm.nih.gov/pubmed/24681597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3490
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