Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of non-camptothecin Topoisomerase I (Top1) inhibitors

In search for a novel chemotype to develop Topoisomerase I (Top1) inhibitors, the pyrazolo[1,5–a]quinazoline nucleus, structurally related to the indenoisoquinoline system precursor of well-known Top1 poisons, was variously decorated (i.e. a substituted phenyl ring at 2– or 3–position, a protonable...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Taliani, Sabrina, Pugliesi, Isabella, Barresi, Elisabetta, Salerno, Silvia, Marchand, Christophe, Agama, Keli, Simorini, Francesca, La Motta, Concettina, Marini, Anna Maria, Di Leva, Francesco Saverio, Marinelli, Luciana, Cosconati, Sandro, Novellino, Ettore, Pommier, Yves, Di Santo, Roberto, Settimo, Federico Da
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982121/
https://ncbi.nlm.nih.gov/pubmed/23987476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400932c
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars