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High yield conversion of doxorubicin to 2-pyrrolinodoxorubicin, an analog 500-1000 times more potent: structure-activity relationship of daunosamine-modified derivatives of doxorubicin.

A convenient, high yield conversion of doxorubicin to 3'-deamino-3'-(2''-pyrroline-1''-yl)doxorubicin is described. This daunosamine-modified analog of doxorubicin is 500-1000 times more active in vitro than doxorubicin. The conversion is effected by using a 30-fold exc...

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Sonraí Bibleagrafaíochta
Main Authors: Nagy, A, Armatis, P, Schally, A V
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1996
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC39820/
https://ncbi.nlm.nih.gov/pubmed/8637897
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