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Design, synthesis, and in vitro evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin

Five peptide fragments, based on the C-terminal sequence of bombesin (BN)-(6-14) or BN-(7-14), were selected as carriers for radicals doxorubicin (DOX) and 2-pyrrolino-DOX to create hybrid cytotoxic analogs. All these compounds had a reduced peptide bond (CH(2)-NH or CH(2)-N) between positions 13 (P...

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Autors principals: Nagy, Attila, Armatis, Patricia, Cai, Ren-Zhi, Szepeshazi, Karoly, Halmos, Gabor, Schally, Andrew V.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences of the USA 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC19568/
https://ncbi.nlm.nih.gov/pubmed/9012839
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