Design, synthesis, and in vitro evaluation of cytotoxic analogs of bombesin-like peptides containing doxorubicin or its intensely potent derivative, 2-pyrrolinodoxorubicin

Five peptide fragments, based on the C-terminal sequence of bombesin (BN)-(6-14) or BN-(7-14), were selected as carriers for radicals doxorubicin (DOX) and 2-pyrrolino-DOX to create hybrid cytotoxic analogs. All these compounds had a reduced peptide bond (CH(2)-NH or CH(2)-N) between positions 13 (P...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Nagy, Attila, Armatis, Patricia, Cai, Ren-Zhi, Szepeshazi, Karoly, Halmos, Gabor, Schally, Andrew V.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19568/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012839/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.652
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!