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Cytotoxic analogs of luteinizing hormone-releasing hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent.

Doxorubicin (DOX) and its daunosamine-modified derivative, 2-pyrrolino-DOX, which is 500-1000 times more active than DOX, were incorporated into agonistic and antagonistic analogs of luteinizing hormone-releasing hormone (LH-RH). The conjugation of DOX with LH-RH analogs was performed by using N-(9-...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Nagy, A, Schally, A V, Armatis, P, Szepeshazi, K, Halmos, G, Kovacs, M, Zarandi, M, Groot, K, Miyazaki, M, Jungwirth, A, Horvath, J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38972/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692981/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.14.7269
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