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Oversulfated Chondroitin Sulfate Binds to Chemokines and Inhibits Stromal Cell-Derived Factor-1 Mediated Signaling in Activated T Cells

Oversulfated chondroitin sulfate (OSCS), a member of the glycosaminoglycan (GAG) family, was a contaminant in heparin that was linked to the 2008 heparin adverse events in the US. Because of its highly negative charge, OSCS can interact with many components of the contact and immune systems. We have...

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Autors principals: Zhou, Zhao-Hua, Karnaukhova, Elena, Rajabi, Mohsen, Reeder, Kelly, Chen, Trina, Dhawan, Subhash, Kozlowski, Steven
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981801/
https://ncbi.nlm.nih.gov/pubmed/24718687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094402
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