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SERCA mutant E309Q binds two Ca(2+) ions but adopts a catalytically incompetent conformation
The sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) couples ATP hydrolysis to transport of Ca(2+). This directed energy transfer requires cross-talk between the two Ca(2+) sites and the phosphorylation site over 50 Å distance. We have addressed the mechano-structural basis for this intramolecular...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
European Molecular Biology Organization
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981149/ https://ncbi.nlm.nih.gov/pubmed/24270570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.250 |
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