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Modulatory and catalytic modes of ATP binding by the calcium pump
We present crystal structures of the calcium-free E2 state of the sarcoplasmic reticulum Ca(2+)-ATPase, stabilized by the inhibitor thapsigargin and the ATP analog AMPPCP. The structures allow us to describe the ATP binding site in a modulatory mode uncoupled from the Asp351 phosphorylation site. Th...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1478189/ https://ncbi.nlm.nih.gov/pubmed/16710301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601135 |
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