Cyclopiazonic Acid Is Complexed to a Divalent Metal Ion When Bound to the Sarcoplasmic Reticulum Ca(2+)-ATPase

We have determined the structure of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) in an E2·P(i)-like form stabilized as a complex with [Formula: see text] , an ATP analog, adenosine 5′-(β,γ-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CPA). The structure determined at 2.5Å resol...

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Hauptverfasser: Laursen, Mette, Bublitz, Maike, Moncoq, Karine, Olesen, Claus, Møller, Jesper Vuust, Young, Howard S., Nissen, Poul, Morth, J. Preben
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Membrane Transport, Structure, Function, and Biogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679452/
https://ncbi.nlm.nih.gov/pubmed/19289472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C900031200
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