SERCA mutant E309Q binds two Ca(2+) ions but adopts a catalytically incompetent conformation

The sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) couples ATP hydrolysis to transport of Ca(2+). This directed energy transfer requires cross-talk between the two Ca(2+) sites and the phosphorylation site over 50 Å distance. We have addressed the mechano-structural basis for this intramolecular...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Clausen, Johannes D, Bublitz, Maike, Arnou, Bertrand, Montigny, Cédric, Jaxel, Christine, Møller, Jesper Vuust, Nissen, Poul, Andersen, Jens Peter, le Maire, Marc
Materialtyp: Artigo
Språk:Inglês
Publicerad: European Molecular Biology Organization 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981149/
https://ncbi.nlm.nih.gov/pubmed/24270570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.250
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk