Nitric oxide regulates cardiac intracellular Na(+) and Ca(2 +) by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism()

In the heart, Na/K-ATPase regulates intracellular Na(+) and Ca(2 +) (via NCX), thereby preventing Na(+) and Ca(2 +) overload and arrhythmias. Here, we test the hypothesis that nitric oxide (NO) regulates cardiac intracellular Na(+) and Ca(2 +) and investigate mechanisms and physiological consequence...

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Detalhes bibliográficos
Main Authors: Pavlovic, Davor, Hall, Andrew R., Kennington, Erika J., Aughton, Karen, Boguslavskyi, Andrii, Fuller, William, Despa, Sanda, Bers, Donald M., Shattock, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981027/
https://ncbi.nlm.nih.gov/pubmed/23612119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.04.013
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