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Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na(+)-K(+)-ATPase
Phospholemman (PLM) is a major target for phosphorylation mediated by both PKA (at Ser68) and PKC (at both Ser63 and Ser68) in the heart. In intact cardiac myocytes, PLM associates with and inhibits Na(+)-K(+)-ATPase (NKA), mainly by reducing its affinity for internal Na(+). The inhibition is reliev...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3006338/ https://ncbi.nlm.nih.gov/pubmed/20861470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00027.2010 |
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