Extracellular potassium dependence of the Na(+)-K(+)-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman

Cardiac Na(+)-K(+)-ATPase (NKA) regulates intracellular Na(+), which in turn affects intracellular Ca(2+) and contractility via the Na(+)/Ca(2+) exchanger. Extracellular K(+) concentration ([K(+)]) is a central regulator of NKA activity. Phospholemman (PLM) has recently been recognized as a critical...

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Detalles Bibliográficos
Main Authors: Han, Fei, Tucker, Amy L., Lingrel, Jerry B., Despa, Sanda, Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2009
Assuntos:
Membrane Transporters, Ion Channels, and Pumps
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740389/
https://ncbi.nlm.nih.gov/pubmed/19570895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00063.2009
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