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Phospholemman-Mediated Activation of Na/K-ATPase Limits [Na](i) and Inotropic State During β-Adrenergic Stimulation in Mouse Ventricular Myocytes
BACKGROUND: Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates β-adrenergic-induced...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854005/ https://ncbi.nlm.nih.gov/pubmed/18362230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.754051 |
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