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Phospholemman-Mediated Activation of Na/K-ATPase Limits [Na](i) and Inotropic State During β-Adrenergic Stimulation in Mouse Ventricular Myocytes

BACKGROUND: Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates β-adrenergic-induced...

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Bibliografiske detaljer
Main Authors: Despa, Sanda, Tucker, Amy L., Bers, Donald M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854005/
https://ncbi.nlm.nih.gov/pubmed/18362230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.754051
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