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Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that the three helical bundles R1–R3 in this regio...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3980218/ https://ncbi.nlm.nih.gov/pubmed/24714394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04610 |
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