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Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that the three helical bundles R1–R3 in this regio...

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Hlavní autoři: Yao, Mingxi, Goult, Benjamin T., Chen, Hu, Cong, Peiwen, Sheetz, Michael P., Yan, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980218/
https://ncbi.nlm.nih.gov/pubmed/24714394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04610
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