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Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy
The dimeric focal adhesion protein talin contains up to 22 cryptic vinculin binding sites that are exposed by unfolding. Using a novel method to monitor the in situ dynamics of the talin dimer stretch, we find that in contrast to several prevalent talin dimer models the integrin-binding talin N-term...
में बचाया:
| में प्रकाशित: | Nano Lett |
|---|---|
| मुख्य लेखकों: | , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5367886/ https://ncbi.nlm.nih.gov/pubmed/27210030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.6b00650 |
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