Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit

Although the roles of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K) signaling in KRAS-driven tumorigenesis are well established, KRAS activates additional pathways required for tumor maintenance, inhibition of which are likely to be necessary for effective KRAS-dir...

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Detalhes bibliográficos
Main Authors: Zhu, Zehua, Aref, Amir R., Cohoon, Travis J., Barbie, Thanh U., Imamura, Yu, Yang, Shenghong, Moody, Susan E., Shen, Rhine R., Schinzel, Anna C., Thai, Tran C., Reibel, Jacob B., Tamayo, Pablo, Godfrey, Jason T., Qian, Zhi Rong, Page, Asher N., Maciag, Karolina, Chan, Edmond M., Silkworth, Whitney, Labowsky, Mary T., Rozhansky, Lior, Mesirov, Jill P., Gillanders, William E., Ogino, Shuji, Hacohen, Nir, Gaudet, Suzanne, Eck, Michael J., Engelman, Jeffrey A., Corcoran, Ryan B., Wong, Kwok-Kin, Hahn, William C., Barbie, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980023/
https://ncbi.nlm.nih.gov/pubmed/24444711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0646
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