Inflammasome priming by LPS is dependent upon ERK signaling and proteasome function()

Caspase-1 activation is a central event in innate immune responses to many pathogenic infections and tissue damage. The NLRP3 inflammasome, a multi-protein scaffolding complex that assembles in response to two distinct steps, priming and activation, is required for caspase-1 activation. However the...

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Autori principali: Ghonime, Mohammed G., Shamaa, Obada R., Das, Srabani, Eldomany, Ramadan A., Fernandes-Alnemri, Teresa, Alnemri, Emad S., Gavrilin, Mikhail A., Wewers, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980013/
https://ncbi.nlm.nih.gov/pubmed/24623131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301974
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