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Inflammasome priming by LPS is dependent upon ERK signaling and proteasome function()
Caspase-1 activation is a central event in innate immune responses to many pathogenic infections and tissue damage. The NLRP3 inflammasome, a multi-protein scaffolding complex that assembles in response to two distinct steps, priming and activation, is required for caspase-1 activation. However the...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3980013/ https://ncbi.nlm.nih.gov/pubmed/24623131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301974 |
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